Grade III hand-foot skin reaction induced by sorafenib*
نویسندگان
چکیده
1 Department of Dermatology, Apollonia University – Iasi, Romania. 2 Department of Dermatology, Institute of Macromolecular Chemistry “Petru Poni” – Iasi, Romania. 3 Department of Dermatology, Nicolina Medical Center – Iasi, Romania 4 Department of Surgery, University of Medicine and Pharmacy of Targu Mures – Mures, Romania. 5 Department of Cardiology, University of Medicine and Pharmacy of Targu Mures – Mures, Romania. 6 Department of Pathology, University of Medicine and Pharmacy of Targu Mures – Mures, Romania.
منابع مشابه
Sorafenib Induced Hand Foot Skin Rash in FLT3 ITD Mutated Acute Myeloid Leukemia-A Case Report and Review of Literature
Sorafenib is a novel small molecule multiple kinase inhibitor which has been used for metastatic renal cancer, hepatocellular cancer. Sorafenib induced skin rash has been discussed as a side effect in trials in both, FLT3 wild type and mutated acute myeloid leukemia (AML), as monotherapy or as combination with other chemotherapeutic agents. We describe a patient with FLT 3 ITD mutated AML, who ...
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Sorafenib (Nexavar®, BAY 43-9006) is a novel, orally administered multi-kinase inhibitor that has recently been approved for the treatment of metastatic renal cell carcinoma. It is also used to delay disease progression in patients with advanced solid organ malignancies and metastatic melanoma. Sorafenib is associated with a relatively high incidence of dermatologic adverse events. The commonly...
متن کاملStrategies for Prevention and Treatment of Chemotherapy-Induced Hand-Foot- Skin-Reaction (HFSR)
Hand-foot-skin-reaction (HFSR), also known as palmoplantar erythrodysesthesia, is a frequently occurring side effect of many antineoplastic therapies. Interruption, dose reduction or even discontinuation of anti-tumor therapy due to missing strategies in prevention or treatment of HFSR can be the consequence. According to severity grade of HFSR restrictions in activities of daily life can occur...
متن کاملHand-foot skin reaction increases with cumulative sorafenib dose and with combination anti-vascular endothelial growth factor therapy.
PURPOSE Sorafenib, a vascular endothelial growth factor (VEGF) receptor-2 and RAF kinase inhibitor, commonly causes skin toxicity. We retrospectively analyzed dermatologic toxicity in patients receiving combined antiangiogenic therapy involving sorafenib and bevacizumab. EXPERIMENTAL DESIGN Castration-resistant prostate cancer and metastatic non-small cell lung cancer patients were accrued to...
متن کاملDevelopment and validation of a prediction index for hand-foot skin reaction in cancer patients receiving sorafenib
BACKGROUND This study describes a repeated measures prediction index to identify patients at high risk of ≥grade 2 hand-foot skin reaction (HFSR) before each week of sorafenib therapy. METHODS Data from 451 patients who received a sorafenib (400 mg bid) as part of a clinical trial were reviewed (Escudier B, Eisen T, Stadler WM et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N En...
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